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October 2, 2025Frontiers in ImmunologyOpen Access

Next generation targeted non-genotoxic conditioning for hematopoietic stem cell and hematopoietic stem cell-based gene therapy

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Authors

JOJennifer OkáľováTSTrent H. SpencerSCShanmuganathan Chandrakasan

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Overview

This review discusses non-genotoxic conditioning approaches in hematopoietic stem cell therapies, highlighting their potential to improve safety and effectiveness.

Key Points

  • Next-generation non-genotoxic conditioning enhances safety in hematopoietic stem cell transplants, reducing infections and toxicities.
  • Compared to traditional regimens, these new methods selectively target HSCs while sparing other crucial cells, promoting better outcomes.
  • Emerging agents such as immunotoxins and monoclonal antibodies show promise in targeted HSC elimination, based on recent clinical breakthroughs.
  • These innovations could significantly expand patient access to hematopoietic stem cell therapies, indicating a shift in treatment paradigms.

Cite This Study

Okáľová et al. (2025) studied this question.

synapsesocial.com/papers/68de6f3183cbc991d0a21ff6https://doi.org/10.3389/fimmu.2025.1653344
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Also Consider

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  1. 1Gene-edited hematopoietic stem cells for leukemia and lymphoma treatment: a systematic review of preclinical and translational evidence2025 · 4 citations
  2. 2From stem cell transplantation to stem cell-based drug delivery systems targeting hematological malignancies: recent advances and clinical considerations2025
  3. 3Reduced-intensity conditioning for allogeneic transplantation in classical Hodgkin lymphoma2025
  4. 4Engraftment of gene-edited hematopoietic stem cells after antibody-drug conjugate conditioning in nonhuman primates2025
  5. 5Hematopoietic stem cell therapy with gene modification to treat sickle cell disease2025