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December 4, 2025Blood AdvancesOpen Access

Engraftment of gene-edited hematopoietic stem cells after antibody-drug conjugate conditioning in nonhuman primates

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Authors

SRStefan RadtkeHKHans‐Peter Kiem

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Overview

Comparison of antibody drug conjugates improved engraftment of gene-edited stem cells in rhesus macaques, indicating potential in HIV treatment.

Key Points

  • Engraftment of gene-edited hematopoietic stem cells was observed after antibody drug conjugate conditioning and busulfan.
  • Myeloablation occurred similarly across conditioning regimens, with time to hematologic recovery preserved.
  • Antibody drug conjugates targeted either CD117 or CD45, showing efficacy compared to standard conditioning.
  • Further refinement of targeted strategies is needed to optimize CCR5 editing for viral immunity.

Cite This Study

Radtke et al. (2025) studied this question.

synapsesocial.com/papers/6930e8b6ea1aef094cca2efdhttps://doi.org/10.1182/bloodadvances.2025017838
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