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October 9, 2025The FASEB Journal

Zanthoxylum Nitidum Ameliorates Intestinal Barrier Dysfunction and Inflammation in TNBS‐Induced Colitis Rats and LPS‐Stimulated Caco‐2 Cells

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Authors

QLQiang LüJYJiao YangWZWU Zhao-di

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Overview

In vivo research reveals Zanthoxylum nitidum reduces inflammation and restores intestinal barrier in TNBS-induced colitis, indicating therapeutic potential.

Key Points

  • Zanthoxylum nitidum significantly enhances intestinal barrier integrity, mitigating harmful effects of ulcerative colitis.
  • In TNBS-induced rats, Zanthoxylum nitidum reduced weight loss and tissue damage more effectively than 5-ASA.
  • Zanthoxylum nitidum activated the PPARγ/SIRT1 pathway while inhibiting NF-κB signaling to reduce inflammatory markers.
  • In vitro, Zanthoxylum nitidum improved barrier function and decreased apoptotic and inflammatory responses in Caco-2 cells.

Cite This Study

Lü et al. (2025) studied this question.

synapsesocial.com/papers/68e70db290569dd607ee60c9https://doi.org/10.1096/fj.202501303rrrr
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