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October 1, 2025Frontiers in NutritionOpen Access

Can Vitamin D supplementation enhance the effectiveness of exercise-induced weight loss in overweight or obese adults? Evidence from integrated transcriptomic and meta-analysis

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Authors

TPTianhang PengZZZi-Ke ZhangWLWenxi Liang

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Overview

Meta-analysis demonstrates Vitamin D may enhance weight loss effectiveness in overweight adults, suggesting further exploration of metabolic mechanisms.

Key Points

  • Combination of Vitamin D supplementation and exercise significantly reduced waist circumference by 1.48 cm.
  • Transcriptomic analysis identified disturbances in Vitamin D metabolism related to skeletal muscle in obese individuals.
  • Subgroup analysis showed greater benefits for older adults and those engaging in aerobic exercise.
  • Findings highlight potential of Vitamin D as a part of weight loss strategies for overweight populations.

Cite This Study

Peng et al. (2025) studied this question.

synapsesocial.com/papers/68dd9537fe798ba2fc499671https://doi.org/10.3389/fnut.2025.1664960
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of vitamin D supplementation on body composition, lipid profile, and glycemic indices in patients with obesity-associated metabolic syndrome: a systematic review and meta-analysis2025
  2. 2Vitamin D3 supplementation enhances the effect of aerobic water-based training on physical fitness indices in obese and overweight menopausal women: A randomized controlled trial2025
  3. 3Vitamin D, Childhood Obesity, and Metabolic Risk – A Scoping Review2025
  4. 4Can vitamin D supplementation affect cardiometabolic factors in children and adolescence with overweight and obesity? A grade-assessed systematic review and meta-analysis of randomized controlled trials2025
  5. 5Effect of resistance exercise on body composition, muscle strength and cardiometabolic health during dietary weight loss in people living with overweight or obesity: a systematic review and meta-analysis2025