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July 21, 2025Diabetology & Metabolic SyndromeOpen Access

Effect of vitamin D supplementation on body composition, lipid profile, and glycemic indices in patients with obesity-associated metabolic syndrome: a systematic review and meta-analysis

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Authors

LGLili GeSGShi GaoNKNajaf Kia

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Overview

Systematic review finds limited effects of vitamin D on lipid profile and body composition in obese individuals, suggesting potential subgroup benefits.

Key Points

  • Vitamin D supplementation generally does not significantly affect metabolic markers in individuals with obesity.
  • Subgroup analyses indicated a potential increase in HDL-C for diabetics and elevated LDL-C in younger adults.
  • Twenty-five randomized controlled trials were included, employing random effects models to analyze data.
  • Despite limited overall effects, certain subgroups may experience beneficial outcomes, highlighting the need for further targeted research.

Cite This Study

Ge et al. (2025) studied this question.

synapsesocial.com/papers/689a060ee6551bb0af8cd40ahttps://doi.org/10.1186/s13098-025-01799-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Can Vitamin D supplementation enhance the effectiveness of exercise-induced weight loss in overweight or obese adults? Evidence from integrated transcriptomic and meta-analysis2025
  2. 2Can vitamin D supplementation affect cardiometabolic factors in children and adolescence with overweight and obesity? A grade-assessed systematic review and meta-analysis of randomized controlled trials2025
  3. 3Vitamin D, Childhood Obesity, and Metabolic Risk – A Scoping Review2025
  4. 4Effectiveness of Vitamin D Supplementation on Biochemical, Clinical, and Inflammatory Parameters in Patients with Different Types of Diabetes: A Systematic Review and Meta-Analysis2025 · 8 citations
  5. 5Effects of Vitamin D3 Supplementation on Inflammatory Markers in Overweight and Obese Children and Adolescents: A Systematic Review2025 · 1 citations