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October 1, 2025Journal of Indian Academy of Oral Medicine and RadiologyOpen Access

A Preliminary Clinicopathologic Study to Evaluate the Association of Human Papilloma Virus in Oral Squamous Cell Carcinoma and Its Influence on Prognostic Significance

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Authors

ACA. Winnifred ChristyUSUma SudhakarSRSnophia Rani Rajamani

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Overview

Observational study explores human papilloma virus role in oral squamous cell carcinoma survival, suggesting prognostic significance.

Key Points

  • HPV may be associated with oral squamous cell carcinoma, indicating its potential role in cancer development.
  • In this study, 14 out of 51 patients showed overexpression of p16, which is linked to HPV presence.
  • Patients with p16 overexpression had slightly improved disease free survival compared to those without.
  • Overall survival was also marginally higher in p16 positive patients, suggesting a potential prognostic advantage.

Cite This Study

Christy et al. (2025) studied this question.

synapsesocial.com/papers/68dd91c7fe798ba2fc498650https://doi.org/10.4103/jiaomr.jiaomr_135_25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Detection of high-risk human papillomavirus genotypes 58 and 59 among oral squamous cell carcinoma patients2025 · 5 citations
  2. 2Impact of HPV Subtypes on Prognosis and Treatment in Oropharyngeal Cancers2025
  3. 3Characteristics and Impact of p16 Expression in Patients With Oropharyngeal Squamous Cell Carcinoma in Tanzania2025
  4. 4Global Prevalence and Modifiers of Human Papillomavirus Positivity in Oral Cavity Cancer: A Systematic Review and Meta-Analysis of Prevalence (1995–2024)2025 · 7 citations
  5. 5A prospective cohort study of HPV-mediated oral and oropharyngeal cancer and efficient detection methods2025