September 20, 2025JCO Global OncologyOpen Access

Characteristics and Impact of p16 Expression in Patients With Oropharyngeal Squamous Cell Carcinoma in Tanzania

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Discussion

Retrospective cohort study assesses p16 expression's role in survival among OPSCC patients, suggesting implications for HPV vaccination.

Patients with p16-positive tumors had a significantly higher overall survival rate of 36% compared to 16.6% for p16-negative cases.
The study indicates a 43.4% prevalence of p16-positive oropharyngeal squamous cell carcinoma in the Tanzanian cohort.
Sociodemographic and clinicopathologic profiles were analyzed to understand p16 expression's impact on prognosis.
Current Tanzanian guidelines lack incorporation of p16 immunohistochemistry testing, despite its prognostic relevance.

Nnko et al. (2025) studied this question.

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