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September 5, 2025CancersOpen Access

Global Prevalence and Modifiers of Human Papillomavirus Positivity in Oral Cavity Cancer: A Systematic Review and Meta-Analysis of Prevalence (1995–2024)

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Authors

AIAreeb IraquiASAlaa SafiaMMMohamad Mahameed

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Overview

Systematic review assesses HPV prevalence in oral cavity cancer globally, highlighting significant variations by age and tumor type.

Key Points

  • HPV prevalence in oral cavity squamous cell carcinoma is 25.8%, with variations by age and tumor characteristics.
  • Younger patients had a higher HPV positivity (29.7%) compared to older patients (23.8%), suggesting a potential age-related susceptibility.
  • Subgroup analyses revealed early-stage cancers had higher HPV prevalence (41.8%) than advanced-stage cancers (10.4%), indicating stage-specific risks.
  • Geographical differences were notable, with HPV prevalence ranging from 73% in Singapore to 7.7% in South Korea, highlighting regional disparities.

Cite This Study

Iraqui et al. (2025) studied this question.

synapsesocial.com/papers/68c239a3b210217d6477d84fhttps://doi.org/10.3390/cancers17172870
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Detection and natural history of HPV infection of oral cavity and tonsils – a systematic literature review2025 · 6 citations
  2. 2Prevalence and Type Distribution of Human Papilloma Virus (HPV) in Oral, Oropharyngeal, Cervical, and Vulvovaginal Cancers2025 · 1 citations
  3. 3Detection of high-risk human papillomavirus genotypes 58 and 59 among oral squamous cell carcinoma patients2025 · 5 citations
  4. 4A prospective cohort study of HPV-mediated oral and oropharyngeal cancer and efficient detection methods2025
  5. 5Impact of HPV Subtypes on Prognosis and Treatment in Oropharyngeal Cancers2025