October 1, 2025ACS Central ScienceOpen Access

Bimolecular Homolytic Substitution (SH2) and Radical Ligand Transfer (RLT): Emerging Paradigms in Radical Transformations

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Authors

AFAnthony J. Fernandes DKDmitry Katayev

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Overview

This perspective highlights recent advances in bimolecular homolytic substitution and radical ligand transfer, indicating their potential for catalysis and selective functionalization.

Key Points

Radical ligand transfer has emerged as a versatile approach for selective functionalization of alkyl radicals, enhancing catalytic applications and reaction efficiency.
Bimolecular homolytic substitution enables effective C–C bond formation by facilitating selective coupling of transient radicals with slower radical partners.
The framework of radical transformations emphasizes the synergy between bioinspired strategies and computational methods for mechanistic improvements and substrate diversity.
Recent advancements and DFT analyses show the potential of combining radical ligand transfer with metal complexes for sustainable transformations.

Cite This Study

Fernandes et al. (2025) studied this question.

synapsesocial.com/papers/68dd91c7fe798ba2fc4983d0 https://doi.org/10.1021/acscentsci.5c01091

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October 1, 2025ACS Central ScienceOpen Access

Bimolecular Homolytic Substitution (SH2) and Radical Ligand Transfer (RLT): Emerging Paradigms in Radical Transformations

View Full Paper

Ask AI

Bookmark

Authors

AFAnthony J. Fernandes DKDmitry Katayev

Discussion

Member takes

Overview

This perspective highlights recent advances in bimolecular homolytic substitution and radical ligand transfer, indicating their potential for catalysis and selective functionalization.

Key Points

Radical ligand transfer has emerged as a versatile approach for selective functionalization of alkyl radicals, enhancing catalytic applications and reaction efficiency.
Bimolecular homolytic substitution enables effective C–C bond formation by facilitating selective coupling of transient radicals with slower radical partners.
The framework of radical transformations emphasizes the synergy between bioinspired strategies and computational methods for mechanistic improvements and substrate diversity.
Recent advancements and DFT analyses show the potential of combining radical ligand transfer with metal complexes for sustainable transformations.

Cite This Study

Fernandes et al. (2025) studied this question.

synapsesocial.com/papers/68dd91c7fe798ba2fc4983d0 https://doi.org/10.1021/acscentsci.5c01091

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