September 10, 2025Angewandte ChemieOpen Access

Radical Borylation of Alkyl Bromides by Photoinduced Halogen‐Atom Transfer

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Discussion

This method enables radical borylation of alkyl bromides with silyl radicals, suggesting broad functional group tolerance.

Radical borylation effectively transforms alkyl bromides, enhancing access to carbon–boron bonds and functionalization.
Mechanistic studies reveal a radical-chain pathway driven by silyl radical-mediated halogen-atom transfer in various unactivated alkyl bromides.
The process allows for significant versatility and functional group tolerance, applicable to diverse primary, secondary, and tertiary alkyl bromides.
Metal-free conditions in this strategy underscore the potential for more sustainable synthetic methodologies in organic chemistry.

Schull et al. (2025) studied this question.

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