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October 1, 2025Medical Journal of BabylonOpen Access

Assessment of Some Aminoglycoside Drugs Repurposing as Helicobacter pylori Urease Enzyme Inhibitors by In silico and In vitro

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Authors

TATamadhur Mohammed Ali Abd AlhasanMAM.K.G. AbbasMMM. Mohammed

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Overview

In silico analysis identified aminoglycosides as urease inhibitors in Helicobacter pylori, suggesting therapeutic potential.

Key Points

  • Aminoglycoside drugs effectively inhibit urease activity in Helicobacter pylori, showing promise in treating infections.
  • Molecular docking results reveal that paromomycin, tobramycin, gentamicin, amikacin, and capreomycin bind strongly to urease's active site.
  • In vitro studies demonstrate dose-dependent inhibition of urease activity, with significant differences observed at P ≤ 0.05 compared to reference strains.
  • The findings highlight a new potential approach for targeting Helicobacter pylori-related gastrointestinal diseases using aminoglycosides.

Cite This Study

Alhasan et al. (2025) studied this question.

synapsesocial.com/papers/68dd89e6fe798ba2fc498173https://doi.org/10.4103/mjbl.mjbl_1067_23
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