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September 10, 2025Current Drug Discovery Technologies

In silico Analysis to Search for an Alternative Inhibitor of Biofilm Production by Helicobacter pylori

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Authors

DBDebasmita BhattacharyaJGJai GuptaAGAnkit Gupta

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Overview

Bioinformatics identifies liquiritin as a potent inhibitor of H. pylori biofilms, highlighting alternatives to conventional antibiotics.

Key Points

  • Liquiritin emerged as a potential inhibitor of H. pylori biofilms, addressing antibiotic resistance.
  • Molecular docking studies revealed Clarithromycin showed the highest binding energy among FDA-approved drugs.
  • ADMET analysis demonstrated that bioactive compounds are safe with minimal toxicity and good pharmacokinetics.
  • The study emphasizes the potential of bioinformatics in discovering novel therapeutic agents for antibiotic-resistant infections.

Cite This Study

Bhattacharya et al. (2025) studied this question.

synapsesocial.com/papers/68c241efb210217d647a174ahttps://doi.org/10.2174/0115701638369494250723071458
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