September 26, 2025Nature CommunicationsOpen Access

Three lncRNAs promote PUM protein condensation and germline differentiation

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Experimental findings reveal three lncRNAs regulate FBF-2 to enhance germline differentiation, implying significant roles in fertility.

Reduced fertility results from combined deletion of three lncRNAs, affecting progenitor cell numbers.
FBF-2, a key regulator, is inhibited through lncRNA interactions, diminishing pro-meiotic transcript levels.
lncRNA mutants exhibit reduced phase separation of FBF-2 within germ cell condensates, impacting fertility.
These findings indicate a cooperative and redundant role of lncRNAs in germline development and protein localization.

Falk et al. (2025) studied this question.

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