The Age‐Associated Long Noncoding RNA lnc81 Regulates Ovarian Granulosa Cell Proliferation and Apoptosis Through TEAD2‐CCN1/2 Pathway in Mice

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Comprehensive analysis reveals lnc81's role in GC proliferation and apoptosis, highlighting connections to TEAD2 and CCN signaling.

lnc81 significantly inhibits granulosa cell proliferation, leading to age-related ovarian aging.
Granulosa cells from older mice showed elevated lnc81 expression linked to apoptosis markers.
RNA-seq analysis and RNA immunoprecipitation established the direct interaction between lnc81 and TEAD2.
This interaction positions lnc81 as a potential therapeutic target for age-related ovarian decline.

Ma et al. (2025) studied this question.

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