September 25, 2025JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIAOpen Access

In-Vitro and In-Silico Study: The Anti-Inflammatory Activity of Ethanol Extract from Cogon Grass Roots (Imperata cylindrica L.

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Authors

SWSiti Warnasih UHUswatun Hasanah SSSiska Juliani Simalango

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Overview

In vitro analysis demonstrated anti-inflammatory properties of cogon grass and molecular docking revealed significant interactions with COX-1 and COX-2 receptors.

Key Points

The ethanol extract of cogon grass roots exhibited an IC50 value of 71.79 µg/mL in inhibiting inflammation.
Molecular docking showed cyclovalone had Gibbs free energies of -9.3 kcal/mol and -9.8 kcal/mol for COX-1 and COX-2, respectively.
The study utilized in vitro protein denaturation inhibition techniques and in silico docking methods to assess anti-inflammatory activity.
Findings indicate that secondary metabolites from cogon grass roots could serve as viable alternatives to traditional NSAIDs.

Cite This Study

Warnasih et al. (2025) studied this question.

synapsesocial.com/papers/68d5e1fbbd7882ccb9b86247 https://doi.org/10.20473/jfiki.v12i22025.264-276

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September 25, 2025JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIAOpen Access

In-Vitro and In-Silico Study: The Anti-Inflammatory Activity of Ethanol Extract from Cogon Grass Roots (Imperata cylindrica L.

View Full Paper

Ask AI

Bookmark

Authors

SWSiti Warnasih UHUswatun Hasanah SSSiska Juliani Simalango

Discussion

Member takes

Overview

In vitro analysis demonstrated anti-inflammatory properties of cogon grass and molecular docking revealed significant interactions with COX-1 and COX-2 receptors.

Key Points

The ethanol extract of cogon grass roots exhibited an IC50 value of 71.79 µg/mL in inhibiting inflammation.
Molecular docking showed cyclovalone had Gibbs free energies of -9.3 kcal/mol and -9.8 kcal/mol for COX-1 and COX-2, respectively.
The study utilized in vitro protein denaturation inhibition techniques and in silico docking methods to assess anti-inflammatory activity.
Findings indicate that secondary metabolites from cogon grass roots could serve as viable alternatives to traditional NSAIDs.

Cite This Study

Warnasih et al. (2025) studied this question.

synapsesocial.com/papers/68d5e1fbbd7882ccb9b86247 https://doi.org/10.20473/jfiki.v12i22025.264-276

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