Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
August 17, 2025Research Journal of Pharmacy and Technology

COX-2 as a Therapeutic Target: An in Silico Approach to Indole Alkaloids for Analgesic Discovery

View Full Paper
Ask AI
Bookmark
Share

Authors

SJSwati JainSSSurender Singh

Discussion

Loading...

Member takes

Overview

Computational analysis reveals strong binding of indole alkaloids to cox-2 in pain management, indicating a drug discovery pathway.

Key Points

  • Inhibiting cox-2 has the potential to reduce pain and inflammation effectively, making it a key therapeutic target.
  • Natural compounds like ajmalicin, vellosimine, and vinorine demonstrate significant binding affinity to cox-2, suggesting therapeutic potential.
  • This approach employs molecular docking to understand how these compounds interact with cox-2, shedding light on their mechanisms of action.
  • Further exploration of these compounds could lead to the development of new anti-inflammatory agents to manage pain.

Cite This Study

Jain et al. (2025) studied this question.

synapsesocial.com/papers/68c23652b210217d64774247https://doi.org/10.52711/0974-360x.2025.00477
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Anti-Inflammatory Mechanisms of Selective Cox-2 Inhibitors: A Preclinical Analysis2025
  2. 2Exploring Potential COX‐2 Inhibitors of Ibuprofen Derivatives: Integrating DFT, Molecular Docking, Molecular Dynamics Simulations, ADMET with FEL and MMPBSA Analyses2025
  3. 3Synthesis and anti-inflammatory, analgesic, and anti-ulcerogenic bioevaluation of new indole bioconjugates2025
  4. 4Quinazolinone derivatives as selective COX-2 inhibitors: In silico analysis using molecular docking, dynamics, and ADMET2025
  5. 5<I>In Silico</I> Molecular Docking Of Beta-Sitosterol and Astaxanthin into Cyclooxygenase Enzymes2025