Evaluation of Immune System Components in Dogs With Protein‐Losing Enteropathy Compared to Healthy Controls

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Prospective study shows lower serum immunoglobulin levels in dogs with protein‐losing enteropathy, indicating compromised immune function.

Dogs with protein‐losing enteropathy exhibited significantly lower serum IgG and IgM levels compared to healthy controls.
Serum immunoglobulin IgG levels averaged 4.5 mg/mL in dogs with PLE, significantly lower than the 19 mg/mL in healthy controls.
Quantitative PCR was used to assess immune cell surface marker expression in peripheral blood mononuclear cells of both groups.
Findings highlight the need to consider immune system abnormalities for effective management of dogs with protein‐losing enteropathy.

Moore et al. (2025) studied this question.

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Prospective study shows lower serum immunoglobulin levels in dogs with protein‐losing enteropathy, indicating compromised immune function.