October 3, 2025Open Veterinary JournalOpen Access

Retrospective evaluation of short- and medium-term therapeutic response to different immunosuppressive and dietary approaches in 148 dogs diagnosed with immunosuppressant-responsive enteropathy

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Discussion

Retrospective analysis identifies treatment protocols and predictors of response in dogs, suggesting dietary approaches play a key role.

79% of dogs showed positive response at 1 month, indicating effective short-term management of enteropathy.
Treatment failure was linked primarily to hypoalbuminemia and hypocobalaminemia rather than the immunosuppressive protocol used.
Different dietary approaches, including hydrolyzed protein diets, demonstrated varying effects on treatment outcomes.
Mortality was mostly observed within 1 month of diagnosis, highlighting challenges in managing chronic intestinal inflammation.

Borella et al. (2025) studied this question.

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