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August 15, 2025

[Characteristics of bronchoalveolar lavage fluid microbial distribution at different disease stages and its relationship with immune function in children with refractory

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Authors

CYChuan YaoYXYufei XiaRXRui Xu

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Overview

Analysis of microbial distribution reveals differences in immune function in children with Mycoplasma pneumoniae pneumonia at various stages, suggesting important clinical implications.

Key Points

  • The relative abundance of Propionibacterium in bronchoalveolar lavage fluid is significantly lower during the acute phase compared to recovery.
  • Streptococcus and Prevotella were notably higher in the acute phase, highlighting shifts in microbial distribution.
  • Microbial richness and diversity decreased during the acute phase, correlating negatively with various immune function markers.
  • Findings indicate that BALF microbiota dynamics in children with Mycoplasma pneumoniae pneumonia are closely linked to immune response.

Cite This Study

Yao et al. (2025) studied this question.

synapsesocial.com/papers/68af40a1cf1dd9ea359ecc86https://doi.org/10.7499/j.issn.1008-8830.2411162
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Macrolide Resistance and Mycoplasma pneumoniae DNA Load in Bronchoalveolar Lavage Fluid on Immune and Inflammatory Responses in Children with Mycoplasma pneumoniae Pneumonia2025
  2. 2The Pulmonary Microbial Signatures of Early Stages of Severe Infection in Children2025
  3. 3Dynamic changes of pulmonary function and immune function in children with mycoplasma pneumonia of different severity and their predictive value for disease prognosis: a retrospective cohort study2025
  4. 4Lung consolidation absorption time in 238 pediatric cases of mycoplasma pneumoniae pneumonia2025
  5. 5Post-COVID-19 disruption of the respiratory microbiome modulates <i>Mycoplasma pneumoniae</i> : a multi-center retrospective investigation study2025