September 25, 2025Open Access

Cannabis and Tobacco Co-Use Predicts Psychosis in Clinical High Risk Cohorts

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Authors

DBDanielle M. Bello SBSophia H. Blyth RRRachel A. Rabin

Discussion

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Implication

Observational analysis showed increased conversion risk to psychosis in clinical high-risk groups with co-use of cannabis and tobacco, highlighting urgent intervention needs.

Key Points

Co-use of cannabis and tobacco significantly increases the risk of conversion to psychosis.
Survival analyses indicated a hazard ratio of 2.53 for co-use contributing to psychosis risk.
Participants with CHR who co-used substances exhibited more severe psychiatric symptoms.
Interventions addressing cannabis and tobacco co-use are crucial for mitigating psychiatric outcomes.

Cite This Study

Bello et al. (2025) studied this question.

synapsesocial.com/papers/68d5d14eddad3c16d46366f7 https://doi.org/10.1101/2025.09.19.25336202

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Implication

Observational analysis showed increased conversion risk to psychosis in clinical high-risk groups with co-use of cannabis and tobacco, highlighting urgent intervention needs.

Cannabis and Tobacco Co-Use Predicts Psychosis in Clinical High Risk Cohorts

Discussion

Member takes

Implication

Key Points

Cite This Study

Cannabis and Tobacco Co-Use Predicts Psychosis in Clinical High Risk Cohorts

Discussion

Member takes

Implication

Key Points

Cite This Study

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