Systematic review and meta-analysis reveal cannabis and tobacco use are linked to reduced brain volume in key regions, indicating potential neurological risks.
Key Points
Cannabis use is linked to smaller amygdala volumes compared to controls, suggesting possible neurobiological effects.
Tobacco users show decreased volumes in the amygdala, insula, pallidum, and total grey matter compared to non-users.
Meta-analyses involve data from 103 studies, with varied exposure and study designs focused on brain volume.
Findings highlight the necessity for further research into the neurological implications of cannabis and tobacco co-use.