A Preliminary Investigation of Tobacco Co-use on Endocannabinoid Activity in People with Cannabis Use

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Preliminary findings reveal higher FAAH levels in cannabis users with tobacco co-use, suggesting negative clinical outcomes.

Tobacco co-use is linked to elevated FAAH levels, potentially worsening clinical outcomes for cannabis users.
Participants with daily tobacco use showed statistically higher FAAH in the substantia nigra and cerebellum, impacting their clinical status.
Positron emission tomography evaluated FAAH levels across multiple brain regions, differentiating between tobacco and cannabis use.
These findings underscore the need to understand how tobacco affects endocannabinoid activity in cannabis users.

Rabin et al. (2025) studied this question.

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