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September 25, 2025Journal of the Science of Food and Agriculture

In vitro dynamic infant digestion model: effects of 1,3‐dioleoyl‐2‐palmitoyl glycerol, lactoferrin, and casein phosphopeptide fortification on infant formula protein and fat digestion

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Authors

SASehar AnwarLZLina ZhangYZYong Zhong

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Overview

This investigation examines protein and fat digestion in infant formulas, indicating that fortification with casein phosphopeptide and lactoferrin enhances digestive similarity to human milk.

Key Points

  • Fortification with casein phosphopeptide, lactoferrin, and 1,3-dioleoyl-2-palmitoyl glycerol improves protein digestion in infant formulas.
  • Protein digestibility in the fortified formulas ranged from 97.6% to 99.08%, with the highest in F2 at 99.08%, comparable to human milk at 98.92%.
  • The study used an in vitro infant dynamic digestion model to assess the effects of fortification on protein and fat digestion patterns.
  • Findings suggest that fortifying infant formulas can enhance their nutritional similarity to human milk, impacting dietary recommendations.

Cite This Study

Anwar et al. (2025) studied this question.

synapsesocial.com/papers/68d5bd6edc445aa9033b0834https://doi.org/10.1002/jsfa.70191
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Also Consider

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  1. 1Human milk vs. cow-milk based infant formula proteins: structure, digestion and physiological impacts2025 · 7 citations
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  4. 4Production of Fortified Plant-Based Infant Formular to Mitigate Malnutrition and Poor Growth Development2025
  5. 5Phospholipid Remodeling and Tri‐Layer Membrane Reconstruction Mediate Cognitive Effects of Humanized Milk Fat Globules in Neonatal Rats2025