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September 25, 2025Open Access

Genomic Surveillance of multidrug-resistant E.coli and Klebsiella in clinical and wastewater isolates from a Pediatric Hospital in Lima, Peru

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Authors

BABrenda AyzanoaCCCamila Castillo-VilcahuamanGSGuillermo Salvatierra

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Overview

Genomic analysis reveals high multidrug-resistant rates in wastewater compared to clinical samples, suggesting significant antimicrobial resistance reservoirs.

Key Points

  • Multidrug-resistant rates were significantly higher in wastewater isolates (73.5%) than in clinical isolates (56.8%), indicating a serious public health concern.
  • A total of 1,302 resistance gene hits were identified, with clinical isolates carrying more antimicrobial resistance genes per genome than wastewater isolates.
  • Genomic analysis showed diverse sequence types among wastewater isolates, including high-risk strains such as ST10, ST131, and ST405, revealing potential risks.
  • These findings underscore the importance of integrating genomic surveillance of wastewater and clinical settings to combat antimicrobial resistance.

Cite This Study

Ayzanoa et al. (2025) studied this question.

synapsesocial.com/papers/68d5bd69dc445aa9033b04fahttps://doi.org/10.1099/acmi.0.001006.v2
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