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September 12, 2025Open Access

Could the load of carbapenemase genes in hospital wastewater be a proxy for the epidemiology of emerging resistance to carbapenems in humans?

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Authors

CFC. FavierMTMylène ToubianaIZIsabelle Zorgniotti

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Overview

Study reveals wastewater surveillance can track antimicrobial resistance genes in hospitals, suggesting predictive potential.

Key Points

  • The presence of carbapenemase genes in wastewater can indicate emerging antimicrobial resistance trends.
  • Quantification of genes like vanA and blaNDM showed patterns consistent with known epidemiological data.
  • Differences in gene levels between hospital buildings reflect varied risk profiles for emerging antimicrobial resistance.
  • Challenges remain for implementing wastewater surveillance as a routine infection control tool in hospitals.

Cite This Study

Favier et al. (2025) studied this question.

synapsesocial.com/papers/68d41dae713b0b5dfea67498https://doi.org/10.1101/2025.09.01.25334728
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Also Consider

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  1. 1Establishing a Practical Approach to Sewer Monitoring for Antimicrobial Resistance Genes and Organisms at Healthcare Facilities2025
  2. 2Detection of Carbapenem-Resistant Bacteria in Skilled Nursing Facility Wastewater2025
  3. 3Metagenomic analysis after selective culture enrichment of hospital and community wastewater enhances antimicrobial resistance gene detection2025 · 5 citations
  4. 4Genomic Surveillance of multidrug-resistant E.coli and Klebsiella in clinical and wastewater isolates from a Pediatric Hospital in Lima, Peru2025
  5. 5Identifying Antimicrobial Resistant Bacteria in Wastewater Influent Samples2025