Simultaneous Estimation of Mebendazole and Levamisole Hydrochloride in Their Pharmaceutical Dosage Form with Greenness Assessment Using HPTLC Method

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Discussion

HPTLC method estimates mebendazole and levamisole HCl in tablets, suggesting precision and accuracy levels.

Assay showed 99.47% accuracy for mebendazole and 99.72% for levamisole hydrochloride.
The method demonstrated linearity in the range of 200-1000 ng/band for mebendazole and 300-1500 ng/band for levamisole HCl.
Chromatographic separation utilized a mobile phase of toluene, methanol, and glacial acetic acid.
Method validation followed ICH guidelines for precision, accuracy, and limits of detection.

Dhivar et al. (2024) studied this question.

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