A Validated HPLC‐PDA Method for Simultaneous Determination of Metronidazole, Miconazole Nitrate, Fluconazole, and Tinidazole: Application in Bulk and in Different Pharmaceutical Dosage Forms

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This validated method detects fluconazole and metronidazole in different pharmaceutical forms, indicating efficient quantification.

The method allows for the simultaneous detection of four antifungal agents in under 8 minutes.
Calibration curves displayed linearity with ranges of 45–135 µg/mL for three agents and 50–300 µg/mL for one agent.
HPLC-PDA method demonstrates high accuracy with recoveries of around 100% for all analytes.
Implemented successfully in marketed formulations, highlighting its practical application and sustainability.

Kulkarni et al. (2025) studied this question.

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