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September 23, 2025Annual Research & Review in Biology

Urinary and Blood microRNAs miR-21, miR-141 and miR-375 as Potential Diagnostic Biomarkers for Prostate Cancer: A Systematic Review and Meta-Analysis

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Authors

ATAïda Djé Djénèba TraoréASAbibou SimporéAZAbdou Azaque Zouré

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Overview

Systematic review evaluates microRNAs miR-21, miR-141, and miR-375, highlighting their potential to improve prostate cancer diagnostics.

Key Points

  • Circulating microRNAs show strong potential as diagnostic biomarkers for prostate cancer, outperforming conventional PSA testing.
  • miR-21 exhibited the highest diagnostic performance with an AUC of 0.92, while miR-141 and miR-375 also showed promise.
  • A total of 25 studies involving 2,697 participants were analyzed, confirming the effectiveness of these microRNAs in prostate cancer detection.
  • Standardized prospective studies are needed to validate the clinical utility of these circulating microRNAs as diagnostic tools.

Cite This Study

Traoré et al. (2025) studied this question.

synapsesocial.com/papers/68d4419f713b0b5dfea805fdhttps://doi.org/10.9734/arrb/2025/v40i92314
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Circulating microRNAs as biomarker in prostate cancer and their significance in the differentiation of benign and malignant conditions of the prostate2025
  2. 2A Brief Review of MicroRNA Profiling in Human Prostate Cancer Tissues and Plasma2025
  3. 3MicroRNAs in Prostate Cancer Liquid Biopsies: Early Detection, Prognosis, and Treatment Monitoring2026
  4. 4Integrating miRNA profiling and machine learning for improved prostate cancer diagnosis2025
  5. 5Diagnostic relevance of Humanin, GAS5 and miR-21/miR-103 in prostate disease risk stratification2025