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August 7, 2025Clinical and Experimental MedicineOpen Access

Diagnostic relevance of Humanin, GAS5 and miR-21/miR-103 in prostate disease risk stratification

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Authors

DCDonatella CoradduzzaSCSara CrucianiLSLeonardo Sibono

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Overview

This research uncovers the diagnostic roles of humanin and gas5 in patients with prostate cancer, indicating potential for better disease stratification.

Key Points

  • Core finding reveals that humanin and gas5 are significantly downregulated in precancerous lesions compared to benign prostatic hyperplasia.
  • Exosomal mir-21 and mir-103 are notably upregulated in prostate cancer, demonstrating high discriminative ability for diagnosis.
  • Methods included analysis of 375 male patients using ROC curves and decision trees to assess biomarker performance.
  • This study suggests that combining these biomarkers could enhance non-invasive diagnostics in prostate disease management.

Cite This Study

Coradduzza et al. (2025) studied this question.

synapsesocial.com/papers/689522189f4f1c896c429cf2https://doi.org/10.1007/s10238-025-01810-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Circulating microRNAs as biomarker in prostate cancer and their significance in the differentiation of benign and malignant conditions of the prostate2025
  2. 2Urinary and Blood microRNAs miR-21, miR-141 and miR-375 as Potential Diagnostic Biomarkers for Prostate Cancer: A Systematic Review and Meta-Analysis2025
  3. 3A Brief Review of MicroRNA Profiling in Human Prostate Cancer Tissues and Plasma2025
  4. 4Integrating miRNA profiling and machine learning for improved prostate cancer diagnosis2025
  5. 5Mendelian randomization reveals causal circulatory microRNAs in prostate cancer pathogenesis and prognosis2025