September 23, 2025PainOpen Access

Neural, psychological, and daily life evidence for a transdiagnostic process of affective dysregulation in depression and chronic widespread pain

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Patients with fibromyalgia and major depressive disorder show similar patterns of affective dysregulation.
The study revealed that stress predicted higher pain levels and worse emotional states in all groups.
Neurofeedback training indicated that patients struggle more to regulate amygdala activity than healthy controls.
Unique deficits in amygdala regulation were observed specifically in fibromyalgia patients.

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Cross-sectional study finds affective dysregulation similarities in fibromyalgia and depression, suggesting shared strategies.

Renz et al. (2025) studied this question.

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