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July 14, 2025

Right Hemispheric Broca's Homologue Mediates Pain-Depression Loop: fNIRS Evidence of Language Network Remodeling in Comorbid Chronic Pain and Depression

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Authors

JZJiaren ZhengNZNing ZhuJHJiaxi Huang

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Overview

This analysis identifies how chronic somatic pain affects the language network and depression in patients, suggesting new therapeutic pathways.

Key Points

  • Chronic somatic pain significantly suppresses the right hemispheric Broca's homologue, impacting language processing in depression.
  • Participants with chronic pain exhibited hypofunction in frontal brain areas during language tasks compared to controls.
  • The study utilized functional near-infrared spectroscopy to assess brain activity during verbal tasks in a large participant group.
  • Findings indicate that changes in the language network may serve as biomarkers for neuromodulation therapy in depression.

Cite This Study

Zheng et al. (2025) studied this question.

synapsesocial.com/papers/689a02afe6551bb0af8cc197https://doi.org/10.21203/rs.3.rs-6998159/v1
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