September 22, 2025Journal of Advanced ResearchOpen Access

Vascular mechanical forces and vascular diseases

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Authors

SLShiwen Liu JCJun Cai ZCZhenzhen Chen

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Overview

This review synthesizes mechanical forces affecting endothelial cells and vascular smooth muscle cells, suggesting implications for diseases like atherosclerosis.

Key Points

Mechanical forces like shear stress regulate the function of endothelial cells and vascular smooth muscle cells, which is vital for vascular homeostasis.
Pathological alterations in mechanical forces contribute to diseases such as atherosclerosis and hypertension by inducing inflammation and dysfunction.
Mechanosensors in cells trigger several signaling pathways that affect processes like proliferation, migration, and apoptosis in vascular cells.
Hydrostatic pressure plays an underestimated role in vascular diseases and highlights critical gaps for future research in mechanosensing.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68d43c95713b0b5dfea7ca4e https://doi.org/10.1016/j.jare.2025.09.013

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September 22, 2025Journal of Advanced ResearchOpen Access

Vascular mechanical forces and vascular diseases

View Full Paper

Ask AI

Bookmark

Authors

SLShiwen Liu JCJun Cai ZCZhenzhen Chen

Discussion

Member takes

Overview

This review synthesizes mechanical forces affecting endothelial cells and vascular smooth muscle cells, suggesting implications for diseases like atherosclerosis.

Key Points

Mechanical forces like shear stress regulate the function of endothelial cells and vascular smooth muscle cells, which is vital for vascular homeostasis.
Pathological alterations in mechanical forces contribute to diseases such as atherosclerosis and hypertension by inducing inflammation and dysfunction.
Mechanosensors in cells trigger several signaling pathways that affect processes like proliferation, migration, and apoptosis in vascular cells.
Hydrostatic pressure plays an underestimated role in vascular diseases and highlights critical gaps for future research in mechanosensing.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68d43c95713b0b5dfea7ca4e https://doi.org/10.1016/j.jare.2025.09.013

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