August 2, 2025Open Access

Pressure Points: Endothelial Responses to Shear Stress and Pressure in Health and Pulmonary Arterial Hypertension

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Experimental analysis reveals shear stress affects PAEC transcription in pulmonary arterial hypertension, suggesting novel therapeutic targets.

Endothelial cells respond to shear stress, aligning under high stress but not low, regardless of disease state.
Transcriptomic analysis shows shear stress alters gene expression patterns in PAECs, differing between control and PAH cells.
Pressure has a modest impact on transcription, with CHD-PAH cells showing notable stress and inflammatory responses.
Sexual dimorphism affects shear responses, indicating that male and female PAECs have different biological pathway enrichments.

Hirsch et al. (2025) studied this question.

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Experimental analysis reveals shear stress affects PAEC transcription in pulmonary arterial hypertension, suggesting novel therapeutic targets.