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September 21, 2025Journal of Nutrition and MetabolismOpen Access

Association of Gut Microbiota‐Derived Short‐Chain Fatty Acids With Persistent Elevated Serum Transaminase Levels in Normal Weight and Obesity: A Pilot Study

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Authors

DSDavid Alberto Díaz de Sandy-GalánHVHugo Villamil‐RamírezMRMaricela Rodríguez‐Cruz

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Overview

Pilot study shows increased short-chain fatty acids in obesity and elevated transaminase levels, suggesting connections to gut health.

Key Points

  • Increased fecal short-chain fatty acids are associated with elevated serum transaminase levels.
  • Groups with obesity showed higher median fecal SCFA concentrations than normal-weight individuals.
  • Specific bacteria, particularly Roseburia, correlate positively with fecal short-chain fatty acids.
  • Further research with larger samples is necessary to clarify these associations.

Cite This Study

Sandy-Galán et al. (2025) studied this question.

synapsesocial.com/papers/68d43c8e713b0b5dfea7c810https://doi.org/10.1155/jnme/6652392
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Metabolic Factors Associated with Alanine Transaminase Levels in Non-Alcoholic Fatty Liver Disease2025
  2. 2Fecal Short-Chain Fatty Acids (SCFAs) and Their Role in Metabolic Disorders: A Systematic Review2025
  3. 3Exploring The Impact of Dietary and Metabolic Risk Factors on Non-Alcoholic Fatty Liver Disease (NAFLD) : A Cross-Sectional Study2025
  4. 4Comparative study of SCFA and butyrate levels in chronic hepatitis versus cirrhosis patients2025
  5. 5Gut Dysbiosis and Plasma Trimethylamine Oxide Are Associated with Subclinical Coronary Atherosclerosis in Obese Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease2025