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August 26, 2025NutrientsOpen Access

Gut Dysbiosis and Plasma Trimethylamine Oxide Are Associated with Subclinical Coronary Atherosclerosis in Obese Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease

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Authors

KIKittiya IslamPKPattida KongsomboonchokeMCManeerat Chayanupatkul

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Overview

Cross-sectional analysis identifies gut dysbiosis and high TMAO levels associated with subclinical coronary atherosclerosis in obese patients with metabolic dysfunction-associated steatotic liver disease.

Key Points

  • Gut dysbiosis and high plasma trimethylamine oxide levels independently associate with high coronary artery calcification scores in MASLD patients.
  • The study compared gut microbiota profiles between low-BMI and high-BMI groups, indicating significant beta-diversity differences.
  • Using magnetic resonance imaging, coronary artery calcification levels were measured in 202 patients with MASLD and no prior cardiovascular disease history.
  • Findings suggest that gut microbiota alterations, along with risk factors like obesity and diabetes, may exacerbate coronary atherosclerosis progression.

Cite This Study

Islam et al. (2025) studied this question.

synapsesocial.com/papers/68af7dec7567bf4f94ff48dahttps://doi.org/10.3390/nu17172759
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