September 10, 2025CureusOpen Access

Fecal Short-Chain Fatty Acids (SCFAs) and Their Role in Metabolic Disorders: A Systematic Review

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Discussion

Systematic review reveals connections between short-chain fatty acids and obesity metrics, suggesting potential therapeutic roles.

Elevated fecal short-chain fatty acid levels correlate with increased adiposity and inflammation.
Targeted supplementation of propionate or butyrate improves insulin sensitivity and reduces energy intake.
The review assessed human studies, including cross-sectional and interventional designs, yielding insights into SCFAs.
Moderate risk of bias identified due to small sample sizes and variability in measurement methods.

Ahmad et al. (2025) studied this question.

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