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September 17, 2025Drug Design Development and TherapyOpen Access

Population Pharmacokinetic/Pharmacodynamic Modeling of Tacrolimus in Renal Transplant Recipients: Impact of CYP3A5 Genotype and Wuzhi Capsule Co-Medication

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Authors

QXQinfang XiangYYYi YangGLGuoxing Li

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Overview

Population pharmacokinetic and pharmacodynamic models reveal the influence of CYP3A5 genotype and Wuzhi capsule on tacrolimus dosing.

Key Points

  • The study established a pharmacokinetic/pharmacodynamic model, quantifying tacrolimus dose-response relationships in renal transplant recipients.
  • Significant covariates affecting tacrolimus clearance included CYP3A5 genotype and co-medication with Wuzhi capsules.
  • Higher initial tacrolimus doses of 3 mg were required for CYP3A5*1 patients, while those with CYP3A5*3/*3 and Wuzhi capsules risked kidney damage even at lower doses.
  • These models provide valuable insights for optimizing individualized tacrolimus dosing in patients with differing genetic profiles.

Cite This Study

Xiang et al. (2025) studied this question.

synapsesocial.com/papers/68d43c79713b0b5dfea7bd2ehttps://doi.org/10.2147/dddt.s542786
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Population pharmacokinetic characteristics of tacrolimus in Chinese lung transplant recipients and optimisation of dosing regimen during the early post-transplantation phase2025
  2. 2Refining tacrolimus dosing through CYP3A5 pharmacogenetics in Taiwanese renal transplant recipients2025
  3. 3Pharmacogenetics Approach for Personalized Tacrolimus Dosing in Heart Transplantation: A Case Report and Literature Review2025
  4. 4Impact of CYP3A5 Gene Polymorphisms on Tacrolimus Pharmacokinetics and Renal Allograft Rejection in Kidney Transplant Recipients: A Meta-Analysis Across Ethnic Populations2025
  5. 5Optimizing Dose Conversion from IR-Tac to LCP-Tac Formulations in Renal Transplant Recipients: A Population Pharmacokinetic Modeling Study2025