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August 26, 2025GenesOpen Access

Pharmacogenetics Approach for Personalized Tacrolimus Dosing in Heart Transplantation: A Case Report and Literature Review

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Authors

NNNives NikpaljJSJure SamardžićNBNada Božina

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Overview

Case report highlights improved tacrolimus levels in heart transplant using pharmacogenetic profiling, suggesting broader applications.

Key Points

  • Genotype-informed tacrolimus dosing improved therapeutic outcomes in a heart transplant patient with prior suboptimal levels.
  • Pharmacogenetic testing revealed CYP3A5 and CYP3A4 profiles, allowing tailored dosing for this patient.
  • Therapeutic drug monitoring confirmed target levels post-adjustment, highlighting benefits of personalized therapy.
  • Routine genotyping may enhance treatment in solid organ transplantation, despite current implementation challenges.

Cite This Study

Nikpalj et al. (2025) studied this question.

synapsesocial.com/papers/68af7dfe7567bf4f94ff556chttps://doi.org/10.3390/genes16091010
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Establishing a <i>CYP3A5</i> genotype–guided tacrolimus dosing protocol in adult kidney transplant recipients2025
  2. 2Refining tacrolimus dosing through CYP3A5 pharmacogenetics in Taiwanese renal transplant recipients2025
  3. 3CYP3A5 genotyping-guided dosing versus weight-based dosing in a multi-ethnic population of kidney transplant recipients2025
  4. 4Recipient Versus Donor <i>CYP3A4/5</i> Genotypes in Adult Liver Transplant Recipients to Achieve Therapeutic Tacrolimus Concentrations Early Post‐Transplant2025
  5. 5Population pharmacokinetic characteristics of tacrolimus in Chinese lung transplant recipients and optimisation of dosing regimen during the early post-transplantation phase2025