Population pharmacokinetic characteristics of tacrolimus in Chinese lung transplant recipients and optimisation of dosing regimen during the early post-transplantation phase

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Analysis reveals optimal dosing regimens in lung transplant patients, highlighting the impact of CYP3A5 metabolism.

Optimal tacrolimus dosing regimens were established using a Monte Carlo simulation based on population pharmacokinetics.
Tacrolimus clearance significantly varied based on CYP3A5 metabolic status, with rapid metabolisers showing much higher rates.
A one-compartment model best described tacrolimus pharmacokinetics, with typical clearance at 7.58 L·h−1.
Concurrent use of azole antifungal drugs notably reduced tacrolimus clearance by up to 58%, indicating a need for careful dose adjustments.

Zhou et al. (2025) studied this question.

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