Activation of the α7 nicotinic acetylcholine receptor mitigates cognitive deficits in mice with sepsis-associated encephalopathy by inhibiting microglial pyroptosis

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Observational analysis shows activation of α7 nAChR improves cognitive deficits in mice, indicating microglial pyroptosis reduction.

Activation of α7 nicotinic acetylcholine receptor reduces cognitive deficits in mice with sepsis-associated encephalopathy.
Caspase-1 knockout and α7 nAChR activation effectively decrease microglial pyroptosis, improving brain function.
The assessment involved evaluating brain tissue oxygen pressure and cytokine levels through Western blotting.
These findings suggest that enhancing microglial mitophagy via α7 nAChR activation could protect against brain hypoxia.

Wang et al. (2025) studied this question.

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