September 18, 2025Molecular Medicine ReportsOpen Access

Capsaicin attenuates sepsis‑associated encephalopathy by inhibiting neuroinflammation and apoptosis whilst activating mitophagy through the BNIP3/NIX pathway

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Discussion

Experimental analysis shows capsaicin reduces neuroinflammation and apoptosis in sepsis, suggesting therapeutic potential.

Capsaicin treatment significantly reduces microglial activation and proinflammatory cytokine levels in sepsis-induced encephalopathy.
In CLP-induced sepsis mice, capsaicin improves cognitive tests while enhancing BNIP3/NIX-mediated mitophagy.
Observational analysis in C57BL/6 mice shows that capsaisin prevents brain tissue destruction related to sepsis.
Findings indicate that targeting the BNIP3/NIX pathway could provide new strategies for treating sepsis-associated cognitive issues.

Zhang et al. (2025) studied this question.

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