September 5, 2025Journal of NeuroinflammationOpen Access

P2X7-CaMKII drives 5-LOX nuclear translocation to impair microglial function after subarachnoid hemorrhage

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Authors

PDPeng-Fei DingNanjing Drum Tower Hospital JZJia-Tong ZhangNorthwestern University XZXiaolong ZhuMerck & Co., Inc., Rahway, NJ, USA (United States)

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Implication

Combining transcriptomics and metabolomics uncovers key pathways affecting microglial function after subarachnoid hemorrhage, suggesting new therapeutic strategies.

Key Points

Activation of P2X7-CaMKII pathways impairs microglial function after subarachnoid hemorrhage, highlighting important therapeutic targets.
5-lipoxygenase nuclear translocation significantly influences lysosomal and microglial function impairment in mouse models of subarachnoid hemorrhage.
Using transcriptomic and metabolomic approaches can reveal critical regulators of microglial activity, showing potential for targeted therapies.
Administering resolvin D1 or targeting P2X7 shows promise in improving neurological and microglial function after subarachnoid hemorrhage.

Cite This Study

Ding et al. (2025) studied this question.

synapsesocial.com/papers/68c23922b210217d6477af74 https://doi.org/10.1186/s12974-025-03530-3

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Implication

Combining transcriptomics and metabolomics uncovers key pathways affecting microglial function after subarachnoid hemorrhage, suggesting new therapeutic strategies.

P2X7-CaMKII drives 5-LOX nuclear translocation to impair microglial function after subarachnoid hemorrhage

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Implication

Key Points

Cite This Study

P2X7-CaMKII drives 5-LOX nuclear translocation to impair microglial function after subarachnoid hemorrhage

Discussion

Member takes

Implication

Key Points

Cite This Study

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