September 20, 2025Open Access

Heterogeneity in inhibition of genetically diverse dengue virus strains by Wolbachia

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Observational analysis reveals varied inhibition of dengue virus strains by Wolbachia, suggesting genetic factors influence control strategies.

Stronger inhibition of genetically diverse dengue virus isolates was achieved with wMelM compared to wAlbB, indicating strain-dependent efficacy.
Median relative dissemination was significantly lower for wMelM (0.04) than for wAlbB (0.19), highlighting strain performance differences.
Substantial heterogeneity in inhibition was observed across 60 DENV isolates, particularly with DENV-3 strains being weakly inhibited.
Differential inhibition by Wolbachia may increase the probability of dengue virus reemergence in settings of high transmission intensity.

Sodeinde et al. (2025) studied this question.

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Observational analysis reveals varied inhibition of dengue virus strains by Wolbachia, suggesting genetic factors influence control strategies.