Plasma Fatty Acid Profiles Modulate PPARγ Expression in Adipose Tissue: A Lipidomic Insight Into Obesity‐Related Metabolic Dysregulation

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Discussion

Cross-sectional analysis reveals links between plasma fatty acids and PPARγ expression in obesity, suggesting metabolic implications.

Obese individuals show higher PPARγ expression in both visceral and subcutaneous adipose tissues compared to nonobese individuals.
Eighteen fatty acids and three new FA-derived factors account for a significant variance in PPARγ expression among obese and nonobese participants.
Saturated fatty acids are linked to PPARγ expression in the subcutaneous adipose tissue of nonobese individuals.
Alterations in plasma fatty acid profiles may play a crucial role in metabolic regulation, especially in obesity.

Sanoie et al. (2025) studied this question.

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