September 5, 2025PLoS BiologyOpen Access

Alterations in ether lipid metabolism in obesity revealed by systems genomics of multi-omics datasets

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Authors

YSYvette L. Schooneveldt SPSudip Paul KHKevin Huynh

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Implication

This study demonstrates how lipid ratios provide insights into obesity, revealing significant associations with ether lipid metabolism and genetic variants.

Key Points

Lipid ratios revealed an inverse relationship between ether lipids and obesity markers, such as waist circumference and body mass index.
Genome-wide association studies connected lipid ratios to genetic variances in the TMEM229B gene, highlighting metabolic pathways involved.
Mouse transcriptomics validated findings from human plasma lipidomics, reinforcing the significance of branched-chain fatty acids in metabolic changes.
The application of multi-omics datasets uncovered alterations in enzymatic activity associated with ether lipid metabolism and obesity.

Cite This Study

Schooneveldt et al. (2025) studied this question.

synapsesocial.com/papers/68c23922b210217d6477af6c https://doi.org/10.1371/journal.pbio.3003349

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Implication

This study demonstrates how lipid ratios provide insights into obesity, revealing significant associations with ether lipid metabolism and genetic variants.

Alterations in ether lipid metabolism in obesity revealed by systems genomics of multi-omics datasets

Discussion

Member takes

Implication

Key Points

Cite This Study

Alterations in ether lipid metabolism in obesity revealed by systems genomics of multi-omics datasets

Discussion

Member takes

Implication

Key Points

Cite This Study

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