Clinical and Autoantibody Profile of Systemic Sclerosis Patients in Saudi Arabia: A Single-Center Retrospective Study

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Discussion

Retrospective study identifies autoantibody associations with interstitial lung disease in systemic sclerosis patients.

The study found that Interstitial Lung Disease is prevalent in 76.2% of systemic sclerosis patients, showing significant organ involvement.
Among 21 patients, 95.2% were female with a mean age of 50 years; diffuse cutaneous systemic sclerosis was the most common subtype.
Frequent autoantibodies included ANA in 95.2%, with strong associations found between these autoantibodies and Interstitial Lung Disease.
The findings highlight the need for larger, multicenter studies due to the small sample size and unique characteristics of this Saudi cohort.

Hussam A. Alsulmi (2025) studied this question.

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