Observational study compares ACA-positive ILD in systemic sclerosis with ATA-positive and ACA/ATA-negative patients, suggesting a more complex prognosis.
Key Points
ACA-positive patients develop ILD earlier than ATA-positive and ACA/ATA-negative individuals.
Compared with other groups, ACA-positive patients had better pulmonary function and fewer severe symptoms.
Survival analysis showed no significant differences among groups, but ACA-negative patients fared better than ACA-positive ones.
Only a small percentage of ACA-positive patients underwent lung transplantation or received stem cell therapy.
Cite This Study
Valera-Ribera et al. (2025) studied this question.