Clinical manifestations and immune correlations in anti-centromere antibody-positive and anti-SSA/Ro antibody-positive primary Sjögren’s syndrome: A retrospective analysis
Retrospective analysis reveals distinct immune profiles in patients with anti-centromere and anti-SSA/Ro antibodies, indicating possible treatments.
Key Points
Patients with anti-centromere antibodies exhibited a higher prevalence of Raynaud's phenomenon and heart dysfunction, highlighting their distinct clinical manifestations.
The analysis included 152 patients diagnosed with primary Sjögren’s syndrome, revealing significant differences in immune parameters between antibody-positive groups.
Retrospective analysis of clinical and laboratory features was employed to establish differences in immune responses among antibody-positive primary Sjögren’s syndrome patients.
Understanding the distinct immune profiles may enable targeted therapies, emphasizing the roles of T cells and NK cells in primary Sjögren’s syndrome.