Spectrophotometric methods for simultaneous estimation of rabeprazole sodium and aceclofenac from the combined capsule dosage form

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Two methods were developed for simultaneous estimation of rabeprazole sodium and aceclofenac, validating accuracy in dosage forms.

The methods achieve high correlation coefficients, with 0.9981 for rabeprazole and 0.9997 for aceclofenac at their respective wavelengths.
Both methods ensure percentage estimates are close to 100%, verifying accuracy in capsule forms with standard deviation under 2.
Validations followed ICH guidelines, assuring reliability in routine application of these spectrophotometric techniques.
Two spectrophotometric techniques were developed: Method 1 utilizing simultaneous equations and Method 2 applying the Q-analysis method.

U et al. (2025) studied this question.

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