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September 5, 2025BMC ChemistryOpen Access

Multivariate classical least squares-based model for spectrophotometric determination of celecoxib and Tramadol in their new formulated dosage form

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Authors

SASaad Ahmed AlAhmedAEAyman Osman ElsayedAAAhmed M. Abdelzaher

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Overview

This method demonstrates accuracy in quantifying celecoxib and tramadol in formulations, suggesting efficient quality control applications.

Key Points

  • The method achieved mean recovery values of 99.85% for celecoxib and 99.99% for tramadol, ensuring high accuracy.
  • Linearity was confirmed in the range of 6–14 µg/mL for both drugs, with detection limits of 0.55 µg/mL for celecoxib and 0.67 µg/mL for tramadol.
  • A classical least squares approach was developed using a chemometric method for effective simultaneous quantification.
  • This study offers a rapid and cost-effective solution for routine quality control of complex pharmaceutical formulations.

Cite This Study

AlAhmed et al. (2025) studied this question.

synapsesocial.com/papers/68c23966b210217d6477bb17https://doi.org/10.1186/s13065-025-01605-z
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